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1

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, Ji-Song, Haggarty, Stephen J., Giacometti, Emanuela, Dannenberg, Jan-Hermen, Joseph, Nadine, Gao, Jun, Nieland, Thomas J. F., Zhou, Ying, Wang, Xinyu, Mazitschek, Ralph

Journal:

Year:

2009

Language:

english

File:

PDF, 1.18 MB

english, 2009

2

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

Zhao, Wen-Ning, Ghosh, Balaram, Tyler, Marshall, Lalonde, Jasmin, Joseph, Nadine F., Kosaric, Nina, Fass, Daniel M., Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J.

Journal:

ACS Chemical Neuroscience

Year:

2018

Language:

english

File:

PDF, 5.36 MB

english, 2018

3

Synthesis and biological evaluation of novel fumagillin and ovalicin analogues

Mazitschek, Ralph, Huwe, Axel, Giannis, Athanassios

Journal:

Organic & Biomolecular Chemistry

Year:

2005

Language:

english

File:

PDF, 192 KB

english, 2005

4

Treatment of Obesity with Celastrol

Liu, Junli, Lee, Jaemin, Salazar Hernandez, Mario Andres, Mazitschek, Ralph, Ozcan, Umut

Journal:

Year:

2015

Language:

english

File:

PDF, 2.71 MB

english, 2015

5

ChemInform Abstract: A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent in vivo Antimalaria Activity.

Sameer Urgaonkar, Joseph F. Cortese, Robert H. Barker, Mandy Cromwell, Adelfa E. Serrano, Dyann F. Wirth, Jon Clardy, Ralph Mazitschek

Journal:

Year:

2011

Language:

english

File:

PDF, 45 KB

english, 2011

6

Antidepressant-Like Properties of Novel HDAC6-Selective Inhibitors with Improved Brain Bioavailability

Jochems, Jeanine, Boulden, Janette, Lee, Bridgin G, Blendy, Julie A, Jarpe, Matthew, Mazitschek, Ralph, Van Duzer, John H, Jones, Simon, Berton, Olivier

Journal:

Neuropsychopharmacology

Year:

2014

Language:

english

File:

PDF, 798 KB

english, 2014

7

On the inhibition of histone deacetylase 8

Guillermina Estiu, Nathan West, Ralph Mazitschek, Edward Greenberg, James E. Bradner, Olaf Wiest

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.27 MB

english, 2010

8

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

Bradner, James E., Mak, Raymond, Tanguturi, Shyam K., Mazitschek, Ralph, Haggarty, Stephen J., Ross, Kenneth, Chang, Cindy Y., Bosco, Jocelyn, West, Nathan, Morse, Elizabeth, Lin, Katherine, Shen, Joh

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 686 KB

english, 2010

9

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

Ecker, Jonas, Oehme, Ina, Mazitschek, Ralph, Korshunov, Andrey, Kool, Marcel, Hielscher, Thomas, Kiss, Judit, Selt, Florian, Konrad, Carina, Lodrini, Marco, Deubzer, Hedwig E, von Deimling, Andreas, K

Journal:

Acta Neuropathologica Communications

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

10

Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype

Santos, Sofia A., Lukens, Amanda K., Coelho, Lis, Nogueira, Fátima, Wirth, Dyann F., Mazitschek, Ralph, Moreira, Rui, Paulo, Alexandra

Journal:

European Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 6.87 MB

english, 2015

11

Turn-On Labeling in Living Cells

Devaraj, N., Hilderbrand, S., Upadhyay, R., Mazitschek, R., Weissleder, R.

Journal:

Year:

2010

Language:

english

File:

PDF, 171 KB

english, 2010

12

A singular system with precise dosing and spatiotemporal control of CRISPR-Cas9

Choudhary, Amit, Manna, Debasish, Maji, Basudeb, Gangopadhyay, Soumyashree Ashok, Cox, Kurt J, Zhou, Qingxuan, Law, Benjamin, Mazitschek, Ralph

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 2.54 MB

english, 2019

13

Naturstoffanaloga als Tyrosinkinaseinhibitoren: Identifikation von IGF1R-, Tie-2- und VEGFR-3-Inhibitoren

Petra Stahl, Lars Kissau, Ralph Mazitschek, Athanassios Giannis, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2002

Language:

german

File:

PDF, 194 KB

german, 2002

14

Small Molecules as Inhibitors of Cyclin-Dependent Kinases

Axel Huwe, Ralph Mazitschek, Athanassios Giannis

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 428 KB

english, 2003

15

Synthesis of Chiral Piperazinones as Versatile Scaffolds for Peptidomimetics

Frank Rübsam, Ralph Mazitschek, Athanassios Giannis

Journal:

Year:

2000

Language:

english

File:

PDF, 133 KB

english, 2000

16

Selective Histone Deacetylase-6 Inhibition Attenuates Stress Responses and Prevents Immune Organ Atrophy in a Lethal Septic Model

Zhao, T., Li, Y., Bronson, R.T., Liu, B., Mazitschek, R., Velmahos, G.C., Alam, H.B.

Journal:

Journal of Surgical Research

Year:

2014

Language:

english

File:

PDF, 196 KB

english, 2014

17

Colorimetric High-Throughput Screen for Detection of Heme Crystallization Inhibitors

Rush, M. A., Baniecki, M. L., Mazitschek, R., Cortese, J. F., Wiegand, R., Clardy, J., Wirth, D. F.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2009

Language:

english

File:

PDF, 132 KB

english, 2009

18

HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions

Tran, A. D.-A., Marmo, T. P., Salam, A. A., Che, S., Finkelstein, E., Kabarriti, R., Xenias, H. S., Mazitschek, R., Hubbert, C., Kawaguchi, Y., Sheetz, M. P., Yao, T.-P., Bulinski, J. C.

Journal:

Journal of Cell Science

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

19

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

Ma, J., Krukowski, K., Golonzhka, O., Laumet, G., Gutti, T., Duzer, J., Mazitschek, R., Jarpe, M., Heijnen, C.J., Kavelaars, A.

Journal:

Brain, Behavior, and Immunity

Year:

2017

Language:

english

File:

PDF, 42 KB

english, 2017

20

Synthesis and biological evaluation of Santacruzamate-A based analogues

Randino, Rosario, Gazzerro, Patrizia, Mazitschek, Ralph, Rodriquez, Manuela

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 754 KB

english, 2017

21

Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis-Related Kinase Inhibitors

Claudia Rosenbaum, Patrick Baumhof, Ralf Mazitschek, Oliver Müller, Athanassios Giannis, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 139 KB

english, 2004

22

Traceless Solid-Phase Synthesis of 2-Aminothiazoles: Receptor Tyrosine Kinase Inhibitors with Dual Selectivity for Tie-2 and VEGFR-2

Frank Stieber, Ralph Mazitschek, Natascha Soric, Athanassios Giannis, Herbert Waldmann

Journal:

Angewandte Chemie International Edition

Year:

2002

Language:

english

File:

PDF, 177 KB

english, 2002

23

Synthesis of [18F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging

Dr. J. Adam Hendricks, Dr. Edmund J. Keliher, Dongpeng Wan, Dr. Scott A. Hilderbrand, Prof. Ralph Weissleder, Prof. Ralph Mazitschek

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 551 KB

english, 2012

24

Cover Picture: Chemical Interrogation of the Malaria Kinome (ChemBioChem 13/2014)

Derbyshire, Emily R., Zuzarte-Luís, Vanessa, Magalhães, Andreia D., Kato, Nobutaka, Sanschagrin, Paul C., Wang, Jinhua, Zhou, Wenjun, Miduturu, Chandrasekhar V., Mazitschek, Ralph, Sliz, Piotr, Mota,

Journal:

Year:

2014

Language:

english

File:

PDF, 512 KB

english, 2014

25

HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells

Iaconelli, Jonathan, Huang, Joanne H., Berkovitch, Shaunna S., Chattopadhyay, Shrikanta, Mazitschek, Ralph, Schreiber, Stuart L., Haggarty, Stephen J., Karmacharya, Rakesh

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.00 MB

english, 2015

26

Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells

Iaconelli, Jonathan, Lalonde, Jasmin, Watmuff, Bradley, Liu, Bangyan, Mazitschek, Ralph, Haggarty, Stephen J., Karmacharya, Rakesh

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 9.12 MB

english, 2017

27

The adaptive proline response in P. falciparum is independent of PfeIK1 and eIF2α signaling

Fagbami, Lola, Deik, Amy A, Herman, Jonathan D, Singh, Kritika, Santos, Sofia A, Bopp, Selina, Lukens, Amanda K., Clish, Clary B., Wirth, Dyann F., Mazitschek, Ralph

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 311 KB

english, 2019

28

In Vivo PET Imaging of Histone Deacetylases by 18 F-Suberoylanilide Hydroxamic Acid ( 18 F-SAHA)

Hendricks, J. Adam, Keliher, Edmund J., Marinelli, Brett, Reiner, Thomas, Weissleder, Ralph, Mazitschek, Ralph

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.94 MB

english, 2011

29

A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly

Groen, A. C., Needleman, D., Brangwynne, C., Gradinaru, C., Fowler, B., Mazitschek, R., Mitchison, T. J.

Journal:

Journal of Cell Science

Year:

2008

Language:

english

File:

PDF, 1.71 MB

english, 2008

30

Electron Tomography of Quantum Dot Bioconjugates

Courtis, A, Mazitschek, R, Bell, D

Journal:

Microscopy and Microanalysis

Year:

2011

Language:

english

File:

PDF, 2.85 MB

english, 2011

31

IBX-vermittelte Oxidation von primären Alkoholen und Aldehyden zu Carbonsäuren

Ralph Mazitschek, Marcel Mülbaier, Athanassios Giannis

Journal:

Angewandte Chemie

Year:

2002

File:

PDF, 80 KB

2002

32

MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo

Vladimir Kirkin, Wilko Thiele, Petra Baumann, Ralph Mazitschek, Katrin Rohde, Guido Fellbrich, Herbert Weich, Johannes Waltenberger, Athanassios Giannis, Jonathan P. Sleeman

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 400 KB

english, 2004

33

Berichtigung: Synthesis of [18F]BODIPY: Bifunctional Reporter for Hybrid Optical/Positron Emission Tomography Imaging

Dr. J. Adam Hendricks, Dr. Edmund J. Keliher, Dongpeng Wan, Dr. Scott A. Hilderbrand, Prof. Ralph Weissleder, Prof. Ralph Mazitschek

Journal:

Angewandte Chemie

Year:

2012

File:

PDF, 177 KB

2012

34

In vivo imaging of specific drug–target binding at subcellular resolution

Dubach, J. M., Vinegoni, C., Mazitschek, R., Fumene Feruglio, P., Cameron, L. A., Weissleder, R.

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 2.47 MB

english, 2014

35

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6

Zilberman, Y., Ballestrem, C., Carramusa, L., Mazitschek, R., Khochbin, S., Bershadsky, A.

Journal:

Journal of Cell Science

Year:

2009

Language:

english

File:

PDF, 1.60 MB

english, 2009

36

Advances in measuring single-cell pharmacology in vivo

Vinegoni, Claudio, Dubach, J. Matthew, Thurber, Greg M., Miller, Miles A., Mazitschek, Ralph, Weissleder, Ralph

Journal:

Drug Discovery Today

Year:

2015

Language:

english

File:

PDF, 1.01 MB

english, 2015

37

Selective inhibition of histone deacetylase 6 attenuates inflammation and improves long-term survival in a lethal septic model

Zhao, Ting, Li, Yongqing, Liu, Baoling, Mazitschek, Ralph, Duan, Xiuzhen, Velmahos, George C., Alam, Hasan B.

Journal:

Journal of the American College of Surgeons

Year:

2013

Language:

english

File:

PDF, 48 KB

english, 2013

38

Antifungal activity of gepinacin-scaffold GPI anchor biosynthesis inhibitors with improved metabolic stability

Liston, Sean D., Whitesell, Luke, McLellan, Catherine A., Mazitschek, Ralph, Petraitis, Vidmantas, Petraitiene, Ruta, Kavaliauskas, Povilas, Walsh, Thomas J., Cowen, Leah E.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2020

File:

PDF, 841 KB

2020

39

Inhibierung der Angiogenese in vivo durch ets-1-Antisense-Oligonucleotide – Hemmung der Expression des Ets-1-Transkriptionsfaktors durch das Antibiotikum Fumagillin

Nicolas Wernert, Antje Stanjek, Serafim Kiriakidis, Anja Hügel, Hem Chandra Jha, Ralph Mazitschek, Athanassios Giannis

Journal:

Angewandte Chemie

Year:

1999

Language:

german

File:

PDF, 170 KB

german, 1999

40

IBX-Mediated Oxidation of Primary Alcohols and Aldehydes To Form Carboxylic Acids

Ralph Mazitschek, Marcel Mülbaier, Athanassios Giannis

Journal:

Angewandte Chemie International Edition

Year:

2002

Language:

english

File:

PDF, 76 KB

english, 2002

41

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

McLellan, Catherine A., Whitesell, Luke, King, Oliver D., Lancaster, Alex K., Mazitschek, Ralph, Lindquist, Susan

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 402 KB

english, 2012

42

Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection

Mosley, A. J., Meekings, K. N., McCarthy, C., Shepherd, D., Cerundolo, V., Mazitschek, R., Tanaka, Y., Taylor, G. P., Bangham, C. R.

Journal:

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

43

Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis-Related Kinase Inhibitors

Claudia Rosenbaum, Patrick Baumhof, Ralf Mazitschek, Oliver Müller, Athanassios Giannis, Herbert Waldmann

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 139 KB

english, 2004

44

Development of a fluorescence polarization based assay for histone deacetylase ligand discovery

Ralph Mazitschek, Vishal Patel, Dyann F. Wirth, Jon Clardy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 116 KB

english, 2008

45

Cover Picture: Characterization of Plasmodium Liver Stage Inhibition by Halofuginone (ChemMedChem 5/2012)

Dr. Emily R. Derbyshire, Prof. Dr. Ralph Mazitschek, Prof. Dr. Jon Clardy

Journal:

Year:

2012

Language:

english

File:

PDF, 729 KB

english, 2012

46

Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

Fass, Daniel M., Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A., Klein, Peter S., Mazitschek, Ralph, Maglathlin, Rebecca L., Lewis, Timothy A., Haggar

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.24 MB

english, 2011

47

Monoalkoxy BODIPYs—A Fluorophore Class for Bioimaging

Courtis, Alexandra M., Santos, Sofia A., Guan, Yinghua, Hendricks, J. Adam, Ghosh, Balaram, Szantai-Kis, D. Miklos, Reis, Surya A., Shah, Jagesh V., Mazitschek, Ralph

Journal:

Bioconjugate Chemistry

Year:

2014

Language:

english

File:

PDF, 3.35 MB

english, 2014

48

8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells

Duan, Z., Bradner, J., Greenberg, E., Mazitschek, R., Foster, R., Mahoney, J., Seiden, M. V.

Journal:

Molecular Pharmacology

Year:

2007

Language:

english

File:

PDF, 597 KB

english, 2007

49

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

James E. Bradner, Raymond Mak, Shyam K. Tanguturi, Ralph Mazitschek, Stephen J. Haggarty, Kenneth Ross, Cindy Y. Chang, Jocelyn Bosco, Nathan West, Elizabeth Morse, Katherine Lin, John Paul Shen, Nich

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.73 MB

english, 2010

50

HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer

Hideshima, Teru, Mazitschek, Ralph, Qi, Jun, Mimura, Naoya, Tseng, Jen-Chieh, Kung, Andrew L., Bradner, James E., Anderson, Kenneth C.

Journal:

Year:

2017

Language:

english

File:

PDF, 3.13 MB

english, 2017

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